Defy Medical vs ProlongMD for Wellness Labs (2026): Cost & Which Wins

Best for Defy Medical

Experienced users who want physician-led TRT or HRT with access to peptides, NAD+, and advanced hormone protocols.

Best for ProlongMD

Users comparing mid-market online TRT programs that still emphasize physician review and lab structure.

Biggest difference

Remote-friendly vs Remote-friendly access model.

Decision helper

Defy Medical: Defy Medical shows a visible starting price of $250 per month, but deeper pricing detail is not fully public on the reviewed pages. ProlongMD: ProlongMD shows a visible starting price of $169 per month, but deeper pricing detail is not fully public on the reviewed pages.

Notable limitations

Defy Medical: Pricing across the full service menu can be complex — initial consult and lab costs are separate from ongoing therapy costs.

ProlongMD: Membership structure can make the first visible price look cleaner than the full long-term cost.

Publicly verified care model notes

Defy Medical: The public flow suggests clinician review or consultation before treatment begins.

ProlongMD: The public flow suggests clinician review or consultation before treatment begins.

Defy Medical: Lab testing is signaled in the visible care model.

ProlongMD: Lab testing is signaled in the visible care model.

Defy Medical: No clear cancellation or refund language was surfaced on the reviewed official pages.

ProlongMD: Cancellation or pause terms were not clearly listed on the reviewed official pages and should be checked directly.

Transparency notes

Defy Medical: Insurance, HSA, or FSA handling was not fully verified from the reviewed official pages.

ProlongMD: Insurance, HSA, or FSA handling was not fully verified from the reviewed official pages.

Defy Medical: Medication changes, shipping, or premium tiers may still change the final bill.

ProlongMD: Medication changes, shipping, or premium tiers may still change the final bill.

Data snapshot — pricing sourced from public provider rates

Last updated

Apr 28, 2026

Providers analyzed

Price range

$250-$300 vs $169

Methodology

How we collect data

Disclosure

Affiliate relationships

Defy Medical

Specialist clinic

A physician-led hormone and longevity clinic with one of the broadest publicly documented service menus in the TRT and peptide space.

Defy Medical is a Tampa-based integrative health clinic with strong national telehealth reach specializing in TRT, HRT, peptide therapy, NAD+ therapy, and comprehensive hormone optimization.

NAD TherapyTRTHRTPeptides

Starting price

$250

per month

Service availability

Telehealth available

Labs included

Tampa, FL

Experienced users who want physician-led TRT or HRT with access to peptides, NAD+, and advanced hormone protocols.

Patients comfortable navigating a clinical, protocol-driven model rather than a consumer-friendly membership app.

See Pricing Details Check Provider

ProlongMD

Official website reviewed

telehealth hormone optimization clinic offering testosterone and longevity-focused treatment planning

ProlongMD is a telehealth hormone optimization clinic offering testosterone and longevity-focused treatment planning.

TRTWellness Labs

Starting price

$169

per month

Service availability

Telehealth available

Labs included

National telehealth

Users comparing mid-market online TRT programs that still emphasize physician review and lab structure.

Visitors who want a longevity-oriented TRT comparison point without jumping to a concierge clinic.

See Pricing Details Check Provider

Signal	Defy Medical	ProlongMD
Wellness Labs price	$250	$169
Price range	$250-$300	$169
Care model	Remote-friendly	Remote-friendly
Membership model	No membership required	Membership required
Availability	1 states + telehealth	21 states + telehealth
Transparency score	4/5	4/5
Limitations	Pricing across the full service menu can be complex — initial consult and lab costs are separate from ongoing therapy costs.	Membership structure can make the first visible price look cleaner than the full long-term cost.

Winner by category

Best for price

ProlongMD currently shows the lower visible wellness labs price anchor.

Best for convenience

Defy Medical looks easier to use for shoppers prioritizing access and lower-friction logistics.

Best for service variety

Defy Medical currently offers the broader service stack around this category.

Best for beginners

Defy Medical looks friendlier for first-time shoppers who want simpler onboarding.

Which should you choose?

Choose ProlongMD if your goal is the stronger overall mix of price clarity and service fit in wellness labs. Choose Defy Medical if its access model or care structure is closer to how you actually want to buy this treatment.

Questions to ask before choosing

Specific to Wellness Labs programs — the service being compared here.

1Is a physician order required, or can I order panels directly?
2Are results reviewed with a clinician, or returned raw with no interpretation?
3What is the cost per panel, and is a membership or bundle more cost-effective?
4Can I use insurance or my HSA/FSA to pay for any of these tests?

Shopper intent shortcuts

Cheapest likely scenario

ProlongMD

ProlongMD currently shows the lower visible wellness labs price anchor, but the real bill still depends on labs, consults, and membership rules.

Fastest access

Defy Medical

Defy Medical looks better for low-friction access if you care most about telehealth and a simpler booking path.

Transparent pricing

Defy Medical

Defy Medical currently publishes the cleaner pricing trail for wellness labs.

More medically supervised

Verify both directly

Both providers need direct verification on clinician review, labs, and follow-up cadence.

FAQ

Wellness Labs comparison questions

Which provider is cheaper for wellness labs: Defy Medical or ProlongMD?

ProlongMD currently shows the lower visible wellness labs price anchor, though the real comparison still depends on membership, labs, and consult structure.

Which provider looks stronger for wellness labs overall?

ProlongMD currently looks stronger on the service-specific comparison because of its current blend of pricing, access model, and overall provider fit.

Why break this out into a wellness labs comparison page?

Because buyers often want a narrower answer than a full-provider comparison when they are only shopping one treatment category.

Related paths

Next comparison clicks

Full provider comparison

Zoom back out to the all-services comparison page.

Defy Medical Wellness Labs

Open the provider's service-specific review.

ProlongMD Wellness Labs

Open the provider's service-specific review.

Wellness Labs guide

Compare the broader service category.

Wellness Labs calculator

Model likely spend for this category.

Next Health Wellness Labs

Compare another provider in this treatment category.

SynergenX Wellness Labs

Compare another provider in this treatment category.

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Function Health Membership Cost: What You Are Actually Paying For

Read related editorial context.

Methodology and disclaimer

Updated Apr 28, 2026

This service comparison page is generated from provider overlap, current price anchors, convenience signals, and treatment-specific fit data. It is designed to be useful for category research, not medical decision-making.

Informational only. Longevity Costs publishes provider research, public pricing context, and comparison summaries for informational purposes only. The site is not a medical provider, clinic, pharmacy, or emergency service. Nothing on this page is medical advice, diagnosis, treatment guidance, or a claim that a therapy is proven, guaranteed, or appropriate for you. Consult a licensed medical professional before starting or changing any therapy.

Source

Public provider websites, rate sheets, and documented offers.

Verification

Verify final pricing directly with the provider before booking.

Cadence

Data is reviewed and updated on a rolling basis.

Sources

Defy Medical homepage

Checked 2026-05-06 · Confidence 68%

Official homepage reviewed for care model and visible public positioning.

Sources

ProlongMD homepage

Checked 2026-05-06 · Confidence 68%

Official homepage reviewed for care model and visible public positioning.

Publicly verified care model notes

Defy Medical: The public flow suggests clinician review or consultation before treatment begins.

ProlongMD: The public flow suggests clinician review or consultation before treatment begins.

Defy Medical: Lab testing is signaled in the visible care model.

ProlongMD: Lab testing is signaled in the visible care model.

Defy Medical: No clear cancellation or refund language was surfaced on the reviewed official pages.

ProlongMD: Cancellation or pause terms were not clearly listed on the reviewed official pages and should be checked directly.

Transparency notes

Defy Medical: Insurance, HSA, or FSA handling was not fully verified from the reviewed official pages.

ProlongMD: Insurance, HSA, or FSA handling was not fully verified from the reviewed official pages.

Defy Medical: Medication changes, shipping, or premium tiers may still change the final bill.

ProlongMD: Medication changes, shipping, or premium tiers may still change the final bill.

Signal

Defy Medical

ProlongMD

Wellness Labs price

$250

$169

Price range

$250-$300

$169

Care model

Remote-friendly

Membership model

No membership required

Membership required

Availability

1 states + telehealth

21 states + telehealth

Transparency score

4/5

Limitations

Pricing across the full service menu can be complex — initial consult and lab costs are separate from ongoing therapy costs.

Membership structure can make the first visible price look cleaner than the full long-term cost.

Winner by category

Best for price

ProlongMD currently shows the lower visible wellness labs price anchor.

Best for convenience

Defy Medical looks easier to use for shoppers prioritizing access and lower-friction logistics.

Best for service variety

Defy Medical currently offers the broader service stack around this category.

Best for beginners

Defy Medical looks friendlier for first-time shoppers who want simpler onboarding.

Questions to ask before choosing

Specific to Wellness Labs programs — the service being compared here.

1Is a physician order required, or can I order panels directly?

2Are results reviewed with a clinician, or returned raw with no interpretation?

3What is the cost per panel, and is a membership or bundle more cost-effective?

4Can I use insurance or my HSA/FSA to pay for any of these tests?

Shopper intent shortcuts

Cheapest likely scenario

ProlongMD

ProlongMD currently shows the lower visible wellness labs price anchor, but the real bill still depends on labs, consults, and membership rules.

Fastest access

Defy Medical

Defy Medical looks better for low-friction access if you care most about telehealth and a simpler booking path.

Transparent pricing

Defy Medical

Defy Medical currently publishes the cleaner pricing trail for wellness labs.

More medically supervised

Verify both directly

Both providers need direct verification on clinician review, labs, and follow-up cadence.